Intra-articular injections of liquid endoprostheses are a relatively new method of treating arthrosis, which is successfully practiced in many European countries. Many drugs are manufactured there and imported to Russia, where they are sold at inflated import prices. Along with them, our country also produces its own liquid endoprostheses, which, according to objective indicators, are in no way inferior, and sometimes even better, than foreign ones. Let's look at this trend using the example of the drugs Noltrex, RusVisk and Gialripayer.
Comparison of the characteristics of liquid endoprostheses "Noltrex", "Gialripayer" and "RusVisk"
| "Gialripayer" | "RusWisk" | "Noltrex" | |
| Compound | Zinc hyaluronate and copolymer of hyaluronic acid with ascorbyl phosphate 1.5%, L-glutathione, L-cysteine, sodium chloride, phosphate buffer, water | Sodium hyaluronate, sodium chloride, sodium dihydrogen phosphate, water | Three-dimensional polyacrylamide 4.5%, silver ions, water |
| Molecular mass | 2 million Yes | 3-3.5 million Yes | More than 10 million Yes |
| Indications | Osteoarthritis without exacerbation, post-traumatic lesions, postoperative conditions | Osteoarthritis stages 1-3 of degenerative or post-traumatic origin | Osteoarthritis at any stage |
| Contraindications | Exacerbations of osteoarthritis, synovitis, hypersensitivity to hyaluronic acid or ascorbyl phosphate | Hypersensitivity to components, taking anticoagulants, inflammation or infection of the joint, skin diseases at the injection site | Inflammation in the joint, one week after arthroscopy, pregnancy and lactation |
| Price for 1 injection ( as of Q1 2019) | 4600 rub. | From 4700 rub. | 3100 rub. |
| Course fee | 12-18 thousand rubles. | 14-23 thousand rubles. | 3100-12 500 rub. |
| Number of injections per course | 3-4 | 3-5 | 1-4 |
| Interval between injections | 14 days | 7 days | 7 days |
| Duration of treatment | 6-8 weeks | 3-5 weeks | 1-4 weeks |
| Duration of effect | 6-12 months | 8-10 months | 6-24 months |
"Gialripayer"
The “Hyalripayer” line from the Russian manufacturer includes many products, mainly for cosmetic purposes – based on hyaluronic acid. Chondroreparant occupies a very modest position among the huge variety of bioreparants.
The drug is hyaluronic acid stabilized using a special technology with ascorbic acid, amino acid and other active components. The drug is used to treat pathologies of joints, periarticular tissues and even the peripheral nervous system. Its action is based on stimulating natural metabolism, as a result of which the properties of synovial fluid improve and the destruction of cartilage slows down.
Note!
Contraindications to the use of chondroreparant include crystal deposition diseases, taking anticoagulants or coagulopathy. It is also prohibited for autoimmune connective tissue diseases.
"Hyalripayer" chondroreparant is recommended for use during extreme physical activity
Compound
"Gialripayer" leaves positive reviews. Users note the natural composition and high quality of the pharmaceutical product. The Hyalrepair line consists of various bioreparation products. They include:
- vitamin C – participates in stimulating collagen synthesis, strengthens blood vessels and acts as a powerful antioxidant, reduces pigmentation;
- lysine, proline, glycine - proteins from the “builder” category, are high-quality and irreplaceable material for protein structures (including elastin and collagen);
- cysteine, glutathione – antioxidant amino acids, protect against the negative effects of ultraviolet radiation and free radicals, reduce pigmentation;
- L-carnitine – burns fat, participates in lipid metabolism;
- vitamin B2 – stimulates the process of tissue regeneration, ensures cellular and tissue respiration;
- modified hyaluronic acid.
The obviousness of the naturalness and usefulness of the components cannot be ignored even by a person who is not interested in medicine, pharmaceuticals or cosmetology. The drug is aimed at treating all possible skin defects caused by dehydration. The product "Hyalripayer", reviews of which are no worse than those of foreign bioremediates, is universal and suitable for any age category and any skin type.
"Hyalrepayer" in numbers
"Gialripayer" has passed clinical trials. The results of a study of the drug for post-traumatic gonarthrosis among athletes are indicative. The course of treatment for osteoarthritis of the knee joint included 3 injections of 2 ml each with an interval of 2 weeks. Using a special scale, the patients’ subjective sensations and objective indicators of the condition of the joint were assessed. The examination was carried out before the start of therapy, before the third injection, 3 and 6 months after the end of the course.
After two injections, the support functions of the injured limb improved in all patients. After 6 months, the pain syndrome completely disappeared, stabilometric parameters became more stable, and proprioceptive function was restored. Biomechanical parameters also showed objective improvement.
The results of using “Hyalripayer” for other diagnoses (arthrosis and periarthrosis of the facet joints, pericoxarthrosis, perigonarthrosis, glenohumeral periarthritis, etc.) are less optimistic:
- in 23% there was a significant improvement (almost complete relief of pain and restoration of joint function);
- in 66.7% – moderate improvement (significant reduction in pain, improvement in function, which requires continued therapy);
- 2.6% of cases had a questionable result (pain returned a week later to the starting point);
- in 7.6% of cases there was no effect.
The drug is indicated for the purpose of blocking pain in diseases of the musculoskeletal system of intra-articular and extra-articular localization. The main condition is the absence of obvious manifestations of the inflammatory process.
"Hyalripayer" chondroreparant has a wide range of indications, in addition to arthrosis
"RusWisk"
"RusVisk" is one of the first Russian drugs based on hyaluronic acid for the treatment of osteoarthritis. In 2009, it was developed by scientists from several specialized scientific institutions, including the State Research Institute of Clinical Immunology, MAA named after. Sechenova and others.
The drug is a special formula obtained using the method of stabilizing hyaluronic acid. Due to this, the latter has increased hydrophilicity for moisturizing cartilage tissue, an antioxidant effect, and excellent mechanical chondroprotective properties.
The developers selected the optimal, in their opinion, concentration of hyaluronic acid - 1.6%. A higher level, according to their research, slows down metabolism, and a lower level deprives the drug of its chondroprotective properties.
The research results showed that 3 weeks after the start of treatment for osteoarthritis of the knee joint, the intensity of pain during movement decreased in 69% of patients. However, the drug showed itself well as a remedy for pain at rest - almost all subjects confirmed that the pain at rest was completely gone. 64% of patients complained of short-term pain at the injection site.
Note!
The instructions for the drug note the incompatibility between hyaluronic acid and quaternary ammonium salts - benzalkonium chloride. Therefore, contact of RusWisk with antiseptics of a similar composition is extremely undesirable. In addition, the manufacturer does not recommend injections into joints with prostheses due to the lack of knowledge of such manipulations.
"RusVisk" is most effective among patients under 60 years of age with arthrosis of 1-2 degrees
Characteristics of Hyalrepair products for bioreparation
The stable structure of hyaluronic acid in combination with caring and beneficial components is produced weighing 14 mg/ml in a volume of 1.5 ml. The substance is enough to treat several areas of the face, décolleté and neck. The kit includes two thin injection needles. The recommended course of treatment is 3 procedures with a rest period of 3 weeks after each. As a preventive measure and to maintain the effect after the main treatment, use the product once every 2 months.
"Gialripayer-02" - designed specifically for sagging and dry skin. In addition to hyaluronic acid, the composition contains: vitamin C, lysine, proline and glycine. A complex of beneficial substances helps combat dehydration, deeply moisturizes and nourishes the skin. The result of treatment is noticeably firmer, more elastic skin with less severe dryness. It is also used as a preparatory stage for chemical peeling and laser treatment. Effectively resolves atrophic scars.
"Gialripayer-04" is actively used in the fight against photoaging. Contains additional components such as cysteine, glutathione and vitamin C. The product allows you to restore the skin after the negative effects of sunlight and the external environment in general: strengthens the walls of blood vessels, smoothes wrinkles, eliminates pigmentation.
"Gialripayer-08" is a bioremediation agent, the reviews of which are very good. Users say this is the best product for oily skin and face contouring. In addition to hyaluronic acid, the composition includes L-carnitine and vitamin C, which have a complex effect on excess fat deposits, promoting their synthesis. It is used not only for the skin of the face, but also for the body: hips, abdomen, elbows, neck - “Gialripayer-08”. Reviews about it confirm its effectiveness on sagging skin. It turns out that light liposuction is possible not only with a scalpel.
"Noltrex"
Noltrex is an artificial endoprosthesis created on the basis of a three-dimensional mesh polymer. The main task of the drug is to replace synovial fluid and compensate for the deficiency of intra-articular lubrication. The composition does not contain hyaluronic acid and other components that are broken down by enzymes in the human body. This explains the extremely long period of action of the synovial fluid prosthesis, reaching two years.
Other benefits of Noltrex include:
- very high molecular weight - more than 10 million Da, due to which the gel remains in its original state for a long time after administration and performs shock-absorbing functions;
- the biocompatible nature of the components, which have neither antigenic nor immunogenic properties, and therefore do not cause allergic reactions;
- affordable price - both for one injection and for the entire course or for the treatment of osteoarthritis for a year.
Noltrex combines the most affordable price and the highest efficiency among Russian liquid endoprostheses
Action provided
Hyaluronic acid, as you know, is the main component of a woman’s beauty. The polysaccharide binds water molecules, thereby maintaining optimal moisture in the dermal cells. In addition, the compound directly affects the production of collagen and elastin - the main proteins the skin needs for elasticity and youth.
With age, as well as due to the harmful effects of the environment, poor lifestyle and frequent stress, the amount of hyaluronic acid in the dermis decreases, which triggers the process of dehydration, which is synonymous with withering and aging of the skin. Following a decrease in the concentration of polysaccharide in the middle layer, the amount of collagen and elastin produced also decreases. The skin becomes flabby, loose and wrinkled, often dry or too oily.
In this case, “Hyalrepayer” comes in handy, a bioreparant, reviews of which give hope to people who have not yet tried its medicinal properties. During the period of its viability (about 3 weeks), the active substances of the drug manage to establish metabolic processes and successfully launch skin regeneration. Acid molecules act as “transport”: they move to the desired cells and give them the necessary nutrients. Collagen synthesis is resumed. Wrinkles are noticeably smoothed out, and small ones disappear altogether.
A little about the price
Russian liquid endoprostheses are often not inferior to imported ones in price, while demonstrating quite high efficiency in the treatment of coxarthrosis, gonarthrosis and arthrosis of other joints. The cost of the first two drugs discussed above (“Gialripayer” and “RusVisk”) is approximately the same; they act for approximately 6-12 months, after which they are eliminated from the body and require a second course.
Those who treat arthrosis with the help of “ Gialripayer” or “RusVisk ” need to undergo treatment 1-2 times a year - say, 3 times in 2 years. With the cost of one course on average 15 thousand rubles. total costs for two years will be 45 thousand rubles. – 22-23 thousand rubles each. for a year . This figure may change in one direction or the other by about 5 thousand rubles, but, one way or another, treatment of arthrosis will cost at least 15 thousand rubles. in a year .
Noltrex is chosen as a liquid endoprosthesis , you will need to undergo a course of treatment once a year, every one and a half or two years. In the most difficult cases, when 4 injections are needed, which does not happen so often, the cost of the course will be 12,500 rubles. This amount will be enough for a year, one and a half or even two years - depending on the condition of the joint, and if there are only two or three injections, then the investment will drop to 7-9 thousand rubles. in year .
Clinic "VivaDent": progressive treatment using modern methods
Are your gums bleeding, your teeth becoming loose, and bad breath causing a lot of inconvenience in your daily life? Are home methods no longer helping? It's most likely time to visit the dentist's office.
Our clinic employs experienced and qualified dentists, including periodontists, who regularly undergo training at various events on the use of innovative methods of treatment and prevention, in particular, with the help of the drug “Dental Hyalripayer” . We prescribe this “miracle drug” to patients in the following cases:
- for chronic periodontitis and gingivitis;
- with inflammation of the gums;
- for the prevention of recurrent periodontal inflammation;
- during resection of the apex of the tooth;
- during patchwork operations;
- in the process of recovery after surgery;
- during dental implantation and in a number of other cases.
It is important to know that such drugs have a number of contraindications. Therefore, their use should be carried out exclusively in a clinical setting under the supervision of a doctor. Make an appointment with our specialists, undergo an examination and receive treatment that will be effective and efficient, safe, painless and affordable!
