Preparations for biorevolumetry appeared on the market relatively recently, but they are beginning to actively gain their positions. The Regenyal idea line of drugs includes both fillers, not all varieties of which are presented in the Russian Federation, and biorevolumetric Bio Expander. A distinctive feature of these products is their high quality, good distribution in tissues, physiology and natural appearance. Let's talk in more detail about the properties that various products of this brand have.
Hyaluronic acid, which is used in the production process, has a very high degree of purification (does not contain protein residues), and as a result, it is hypoallergenic and excellent tolerability. It is obtained by bacterial biofermentation (the level of bacterial endotoxins is less than 0.05 EU/mg), cross-links are formed by the standard method - using 1,4 - butanediol diglyceride ether, but its concentration is low - less than 0.1 ppm. The unique technology uses hyaluronate chains with different molecular weights, which are standardized as 1 million Dalton and 2 million Dalton. They are combined into one phase with a single spatial stereochemical configuration. Thanks to this, it was possible to obtain a special mesh structure that is highly elastic and can remain in tissues for a long time in comparison with stabilized hyaluronic acid chains, which have a non-standard length. Also, a buffered saline phosphate solution with pH 4.7 is used as a stabilizer in the line of products. The concentration of hyaluronic acid is 25 mg/ml.
Manufacturer: Regenyal laboretories in collaboration with Fidia Farmaceutical, Italy. Analogues: hyaluronic fillers, such as Restylane, can be cited as analogues, while an analogue for Bio Expander is the drug Ial System DUO, which also belongs to the class of biorevolumetrics.
Regenyal Idea line of drugs
Regenyal Idea in the classic version, which was the first to see the light, is available in two volumes - 0.6 ml and 1 ml. For injections, it is recommended to use a 27G needle. As already described above, the structure of the drug is a kind of lattice formed by orderly arranged chains of hyaluronic acid with a length of 1 and 2 million Daltons, respectively. This three-dimensional design is stable, ensured by the best arrangement of BDDE “cross-links” between the hyaluronate chains and has all the properties necessary for volumetric correction - it is well distributed in tissues, easy to inject, and provides volume. The drug is intended for introduction into the middle and deep layers of the dermis; it is capable of correcting medium and deep wrinkles, restoring volume, having a high degree of versatility.
Regenyal Idea Bio Expander appeared a little later than its predecessor. In addition to hyaluronate chains of 1 and 2 million Daltons, it contains native hyaluronic acid, 500 kDa. Its amount in the preparation is no more than ten percent; it is designed to provide a moisturizing effect and, as a result, tissue rejuvenation and biorevitalization. Bio Expander is available in 1.1 ml syringes. Three syringes in one package. The kit also includes a 27G x 40mm cannula. The drug can also be administered using a 30G needle due to good extrusion. The depth of injection is the superficial hypodermis, where the three-dimensional network of the gel interacts with the overlying and underlying tissues (dermal layer and subcutaneous tissue), gently restoring tissue volume and improving skin quality. Bio Expander is the drug of choice for the correction of structural hypovolumic disorders, when tissue volume deficit is combined with involutive changes (for more details, see the material on biorevolumetry).
Regenyal idea lips is a product in the line, specialized for the lip area. The volume of the syringe is 1 ml, it is recommended to use 27G and 30G needles. Contains hyaluronate in the form of linked BDDE (30%) chains with a molecular weight of 1 million Daltons, as well as native hyaluronic acid, 500 kDa. This gel is administered using the Linear Lip technique, which helps to increase the volume of young lips with a clear contour and absence of wrinkles. For the same purpose, you can use the classic Regenyal Idea.
Composition of the drug
Biorevolumetric regenyal idea is suitable for contour tightening of the oval and local correction of problem areas. Produces a general therapeutic effect, makes the skin more well-groomed and moisturized.
The drug contains 2 types of hyaluronic acid. Components of non-animal origin ensure minimal risks of allergic reactions. The introduction of filler guarantees the restoration of hydrobalance and transformation of the skin.
The raw materials for regenial lipsticks are produced by Fidia Farmaceutical. No protein impurities were found among the components.
Regenyal idea: insertion techniques
1. To restore volume in the cheek-zygomatic region, a pyramidal insertion technique is used. With this technique, we imagine a pyramid, with the base upward (towards the orbital area) and the apex directed towards the upper lip. The area of this imaginary pyramid is filled with the drug using linear injections. Special training seminars are held for specialists with a detailed analysis of the technical features of the work. When using this technique, the cheeks are smoothed due to a natural increase in tissue volume and some smoothing of the nasolabial fold. This ensures a natural appearance of the face at rest and during facial activity. 2. There is also a special technique for working with wrinkles around the lips, which is called “vertical”. With it, the needle is inserted perpendicular to the surface of the skin to the depth of the wrinkle and the void under it is papularly filled with the drug, which leads to smoothing the surface of the skin. The distance between the injections should be about 3-4mm to ensure uniform filling of the volume defect.
Recovery
The recovery period takes several days. It is not recommended to drink hot drinks, take a hot shower or bath. And also refrain from baths and solariums. The doctor prescribes the use of cold compresses and special pharmacy creams to minimize swelling and the possible appearance of “bruises”.
You should abstain from alcohol and aspirin for several days. And if the doctor has not prescribed a massage for this area, then try to limit touching your lips as much as possible and not use lipstick. For several days you should wipe your lips with chlorhexidine or another antiseptic, as prescribed by your doctor.
Regenyal Idea: reviews
There are many good reviews from specialists about these drugs due to their high quality and special properties. If we talk separately about Bio Expander, it really gives a natural result during correction, which does not affect facial expressions and lasts for quite a long time (up to 1 year). It should, however, be understood that these products also have limitations in their use, that is, they are not able, for example, to correct expression wrinkles, which Dysport effectively affects. Biorevolumetry is one of many techniques that can be combined with other influences. In cosmetology, nothing is a panacea; everything must be used for its intended purpose in the right place and at the right time.
Indications, effectiveness of use
The filler is indicated for women in the age group of 30-70 years. It can be used for lip augmentation from the age of majority, that is, from 18 years of age. The drug allows you to cope with:
- Violations of the oval contour, lack of volume in certain areas.
- Asymmetrical, inharmonious features.
- Noticeable ptosis.
- Wrinkles of varying depths and locations.
- Photopigmentation.
- Lumpy skin structure, sensitivity, dryness and flaking.
The line of drugs includes:
- Regenial Idea. Used by cosmetologists to eliminate medium and deep wrinkles. Useful for restoring volume and increasing tissue elasticity. The duration of the rejuvenating effect is up to 9 months.
- Bio expander. Serves for biorevolumetry and combating age wrinkles. Allows you to create stiffening ribs and local volume, helps to correct the oval of the face. Removes creases in the bridge of the nose and nasolabial triangle. The effect after the introduction of Bio expander is similar to the results of surgical plastic surgery. It can be injected not only into the skin of the face, but also into the neck and décolleté area.
- Regenial idea lips. The low viscosity composition serves to increase lip volume. Removes folds in the delicate perioral area. Monophasic gel improves the condition of thin skin. The effect after filler injection lasts for 1 year.
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Regenial idea lip augmentation reviews
The manufacturers of the line of injection drugs under the Regenyal Idea trademark are two Italian and Fidia Farmaceutical.
Regenyal Laboratories has patented a unique technique for cross-linking molecular chains of hyaluronic
acids into a three-dimensional model that provided:
-almost zero presence of BDDE cross-linking molecules in the final product; -production of highly purified products that do not contain foreign impurities; - guarantee of sterility of the contents in the syringe.
The raw material is HA, not of animal origin, but of synthetic origin, biofermented from bacteria, produced by Fidia Farmaceutici, a recognized world leader in its synthesis.
The company is the holder and owner of International Patent Law Manufacturing and Synthesis
highly purified hyaluronic acid, which does not have protein impurities.
During the high-tech production cycle, raw HA is stabilized by cross-linking HA molecules with the BDDE component (1,4-butane-diol-diglycide-ether) and subsequent stabilization of the resulting network structure with neutral acidic phosphate salts.
Once the acid has gone through all the technological operations, it acquires new properties: it becomes more resistant to degradation by enzymes, but remains biocompatible and safe.
Advantages of Regenyal Idea:
High security
The high degree of safety of Regenyal Idea fillers is confirmed by documents
and testing: a patented technique that ensures a minimum of crosslinking content, chemical purity and sterility. The production of fillers is carried out using high-tech equipment, each stage of the process is controlled, which increases its reliability and quality.
In addition, the safety of the drugs is confirmed by the registration certificate of the Ministry of Health of the Russian Federation: Federal Law No. 2010 / 06068 from 258243; January 2011
Dermal fillers have been registered in Russia as medical products for intradermal use. Reg.ud: fsz No. 2010 / 060 668 dated 01/25/2010
The use of Regenial Idea biogels eliminates the risks of complications directly related to the administered drug.
Plasticity and homogeneity
Manufacturers, by mixing two differently weighted forms of HA in one suspension and stitching them into a single volumetric lattice, obtain a gel characterized by excellent plastic properties. This innovative approach also made it possible to reduce the amount of BDDE cross-linking agent used, due to the rational placement of cross-links of cross-link molecules with hyaluronic chains of different lengths.
As a result, the structure of the preparations is a 3D network consisting of HA molecular chains of different lengths, and dermal fillers acquire special plasticity, which allows them to be evenly distributed in tissues, and homogeneity, which facilitates administration.
Durability
a molecular framework for fillers that is weakly responsive to destructive The three-dimensional lattice structure is quite strong and resistant to the body's degrading enzymes.
Chemical purity of the suspension
During the examination of the drugs, the following was revealed:
homogeneous, colorless gel; HA 2.5% (25.0 mg/ml); two molecular sizes of HA: 1215;106 Da, 2215;106 Da; output volume: 0.60 ml. / 1.00 ml; packaging: one spr. + two needles 27G; injected into the deep/middle dermal layers; biodegradation: up to 9 months.
Reducing the severity of medium/deep wrinkles; smoothing out deep folds and creases; restoration of volume, facial architectonics in the area: cheekbones, cheeks, corners of the mouth, chin, nasolabial area.
homogeneous, colorless gel; HA 2.5%; three types of HA molecules: 1215;106 Da, 2215;106 Da and native HA: 500kDa (max. 10% of all HA); output volume: 1.10 ml; packaging: three spr. + one cannula 27G 40 mm; silt 30G is acceptable; entry into the superficial hypodermis; biodegradation: up to 12 months.
Used for: restoration; volumetric modeling; hydration. Smoothes: nasolabial folds; wrinkles in the periorbital area; scars, post-acne and scars. Corrects: manifestations of rosacea (vascular network on the face). Sculpting and volume correction: Cheeks; School; Chin; Lip.
monophasic transparent gel; stabilized HA 2.50% (25.0 mg/ml); HA molecules: 1215;106 Da and native HA: 500kDa; output volume: 1.00 ml; packaging: one syringe + one 27G needle; 30G sludge can be used; injection into the superficial hypodermis; period of complete biodegradation: up to 12 months.
Has pronounced long-term hydration of tissues. Natural correction of lip shape; adding volume to young lips, in the absence of wrinkles and a clear contour; alignment of the lip relief.
What is the price
- Regenyal Idea price: 9.0 thousand rubles;
- Regenyal Bio Expander price: 12.50 rubles;
- Regenyal Idea- Lips price: 13.50 rubles;
- filling the required volumes;
- creating a strength frame;
- skin hydration, improving its quality;
- "lifting effect".
Ten "Yes!" in favor of Regenyal idea:
1. There is no need for preliminary allergy testing before inserting these implants. 2. Complications and other negative side effects with Regenial Idea injections, possible with fillers with variable viscosity and density, were not identified here. 3. Multiple actions in one ampoule:
4. Versatility. Using one biogel for different types of aesthetic defects. 5. Restoring the natural contours of the face, rather than “pumping up” wrinkles. 6. Do not interfere with active facial expressions. 7. Suitable for face, neck, décolleté, hands. 8. Compatible with any skin: from thin, dry to thick. 9. Not felt when touched, invisible visually. 10. Indicated for patients of different ages: from 35 to 75 years.
Photos before and after
Characteristics and composition
The structure of the substance provides for the presence of molecules with different masses (1 × 106 Da and 2 × 106 Da). It looks like a lattice of HA chains of different lengths.
The main ingredient of the drug is stabilized hyaluronic acid obtained by bacterial fermentation. The same raw materials are used in the production of IAL-System injection products from Fidia Farmaceutici, they are characterized by a high degree of purity and safety. The preparation contains not only proteins and nucleic acids, but also other harmful ingredients: acetone, ethanol and chlorine. The composition is non-toxic and does not affect the blood.
The crosslinking agent BDDE has a low concentration, which gives the substance hypoallergenic properties. The presence of bacterial endotoxins does not reach a value of 0.005 EU/m. The pH level is 7.3. HA content - 25 mg/ml.
The release form of the Regenyal Idea filler is a homogeneous transparent soft gel in 0.6 and 1 ml syringes. Injections are carried out with a 27G needle. The material has been sterilized and is ready for use.
Plasticity and homogeneity.
Two forms of hyaluronic acid are used, having different molecular weights (2x106 Da, 1x106 Da), which are activated and cross-linked into a single phase. The mass obtained in this way is characterized by a uniform distribution of cross-links and the presence of a single stereochemical spatial configuration (due to the presence of chains of hyaluronic acid molecules of different lengths), providing calibrated and constant plastic properties, which is a very valuable quality for facilitating changes in tissue volume.
