Replery is a product from a series of intradermal fillers, which is based on stabilized hyaluronic acid of non-animal origin. The drug was created to solve aesthetic skin problems and is presented in the form of a gel with different levels of viscosity, for administration by injection. The Repleri line of dermal implants is represented by five drugs that are used to correct skin problems - wrinkles, folds, improve facial contours and areas of lipodystrophy. Replery is also used to correct the shape and size of the lips, eliminate skin imperfections associated with aging (neck, forehead, nose, area around the eyes and mouth, earlobes, back of the hand and foot). The products in the series are designed to create the correct facial contour, fill deep wrinkles and folds, increase lip volume and rejuvenate facial skin. Each type of Replery drug is individually designed to eliminate specific skin problems. Filler injection can be performed on the face or other areas of the skin. Manufacturer: Preparations of the Repler line were developed by the Russian organization NovoNexus LLC - NovoNexus Co., Ltd and are manufactured in China by Shanghai Qisheng Biological Preparation, Co. Ltd., where there is a high-tech production base.
Analogs: all preparations for contouring are based on hyaluronic acid, most of all biphasic, for example, Perfecta, Restylane.
Drug review
Replery intradermal fillers are patented by Russia, but the production of the drugs itself is carried out in China due to the large capacity and capabilities of the production equipment.
The fillers contain hyaluronic acid as the main substance, produced through the synthesis of raw materials of non-animal origin. The role of an additional component is played by physiological sodium chloride solution.
Buyanov Sergey Yurievich (Expert Doctor):
The product does not contain additional elements, so it is less likely to cause an allergic reaction.
Composition and properties of repleri fillers
Repler fillers contain stabilized hyaluronic acid, saline solution, cross-linking agent (in varying concentrations) and sodium chloride. The amount of cross-linking agent is different for each filler in the Replery line.
Important: to achieve the most pronounced positive result, it is necessary to select the correct number of repler filler and follow the injection technique. Otherwise, insufficient depth of needle insertion may cause an incomplete aesthetic effect of the rejuvenation procedure.
The introduction of repler fillers helps achieve the following results:
- completely smooth out shallow wrinkles;
- correct facial contour;
- change the shape of the earlobes, wings of the nose;
- eliminate tissue ptosis;
- enlarge lips.
Types of fillers
The line of Russian dermal gels is represented by several fillers, hyaluronic acid in the same ratio.
The ability to solve various problems is due to the size of hyaluronic molecules and the strength of the bond between them.
Repleri №1
A drug characterized by the smallest dimensions of hyaluronic molecules among the entire line. It is used in mesotherapy, biorevitalization and contouring procedures.
The filler is a soft dermal filler, the main substance of which is adhered to in small sections.
Injections are carried out with a 30G needle into the upper skin layers.
Suitable for use from 25 years of age. Target:
- eliminates superficial wrinkles;
- corrects imperfections in delicate areas around the lips and eyes;
- additionally used for easy rejuvenation and for preventive purposes against natural aging.
Repleri №2
A gel with medium-sized hyaluron particles, which is why the category of needles also changes. In this case, the cosmetologist uses 29-27G.
The drug is intended for the age group of 30-35 years. Ideal in the first stages of aging.
The use of filler allows you to change the shape of your earlobes, get rid of a pronounced lip contour, and correct medium and superficial wrinkles and skin folds.
It is also possible to increase the volume of the lips with filler and lift the eyebrows non-surgically. It is extremely rarely used in biorevitalization and mesotherapy.
Repleri №3
The filler is characterized by medium density and high plasticity, which is why it is actively used in contour plastic surgery.
The drug is injected into the middle layers of the skin (27-26G needle). Indicated for people over 35 years of age.
Purposes of using Replevi No. 3:
- correction of pronounced wrinkles and skin creases;
- sculpture of cheekbones, earlobes, nose;
- reinforcement of facial oval lines;
- increase in lip volume.
Repleri №4
Another product in this line, designed for facial modeling (use is permissible from 45 years).
The drug is injected with 24-25G needles into the deep layers of the dermis and onto the periosteum. It has a thick consistency and excellent viscosity.
Helps reconstruct the facial contour, replenish the lack of lipid tissue and smooth out wrinkles of varying degrees. Sculpting in the area of the cheekbones, temples and chin is also possible.
Repleri №5
The filler is characterized by maximum density, which is achieved due to large molecules of hyaluronic acid.
The product is used from 45-50 years. It is suitable for contouring.
As a result of injections, deep wrinkles and depressions are filled with the drug. It is possible to correct volume deficits in the cheekbones, temples, cheeks and chin.
Repleri Lip
A specially developed filler with a soft texture, intended for correction of the perioral zone.
Used to increase lip volume or correct contour. It is acceptable to use as a preparation for contour plastic surgery of a non-global nature on the lower ⅔ of the face.
Types of fillers and purpose
The main advantage of repler fillers is the variety of types, allowing the client to choose the ideal drug for themselves with the required labeling.
Replery filler is available in five forms (numbered with corresponding numbers). Depending on the concentration of the stabilizer, the product is indicated for the correction of various zones.
Repleri 1
Repler filler 1 is distinguished by the size of the (small) hyaluronic acid molecules. The drug is indicated to eliminate the first age-related changes for patients no older than twenty-five years. The filler is injected into the layers of the skin using a 30G needle.
Replery N 1 is actively used in contouring and mesotherapy. Its introduction helps to quickly eliminate the following problems:
- wrinkles around the eyes;
- deep folds on the forehead;
- blurred lip contour.
Replery 1 is an ideal option for patients who want to eliminate even the most minor signs of skin aging. The positive effect of the filler injection procedure lasts from nine to twelve months.
Repleri 2
The drug differs from Replery 1 filler in the larger size of the hyaluronic acid molecules. Replery 2 is indicated for insertion into the deep layers of the skin; a 29G needle is used for this. The drug is indicated for contouring. The introduction of this filler helps correct the following cosmetic defects:
- increase lip volume;
- smooth out the wrinkled network around the lips;
- smooth out wrinkles on the bridge of the nose;
- adjust the shape of the earlobe.
The drug is indicated for use by patients over thirty-five years of age. The positive results from the procedure can last up to one year.
Repleri 3
Continuing the line of replery drugs, filler number three also differs in the size of the hyaluronic acid molecules (they are larger than in previous fillers). To insert replery 3, a 26 G or 27 G needle is used.
Filler injection helps:
- smooth out pronounced wrinkles;
- correct skin that has lost its elasticity in the nose area;
- correct facial contour;
- enlarge lips;
- eliminate the manifestations of age-related ptosis.
Injections are indicated for patients over thirty-five years of age. The positive effect of the procedure lasts up to twelve months.
Repleri 4
Filler number four, characterized by the largest molecules of hyaluronic acid, is injected into the deep layers of the dermis, the periosteal flap. The drug is administered using a 25G needle.
Repler 4 helps you achieve the following results:
- adjust the shape of the chin and cheekbones;
- correct facial contour;
- replenish lipid tissue density;
- eliminate deep wrinkles;
- smooth out scars, traces of mechanical damage to the skin;
- correct drooping tissues, fill in the missing volumes of sunken cheeks.
Replery 4 for the purpose of skin rejuvenation, filler can be administered to women over forty-five years of age. The positive effect of the procedure lasts up to one and a half years.
Repleri 5
Filler number five is injected using a 23G needle into the deep layers of the skin. The injection procedure is an ideal solution to the problem of the missing volume of subcutaneous fat.
Effect of introducing replery 5:
- correction of earlobe shapes;
- modeling the contour of the cheeks, nose, chin;
- replenishment of the missing volumes of areas that have lost lipid tissue as a result of aging.
Filler number five is well suited for patients over fifty years of age. The rejuvenation effect lasts up to eighteen months.
Indications for use
In most cases, Repleri is used for contouring, but it is also possible to use rejuvenating cocktails for biorevitalization and mesotherapy procedures.
The use of fillers is indicated for:
- scars;
- wrinkles of various types;
- enlarged pores;
- unhealthy skin tone;
- pronounced gravitational ptosis;
- skin creases;
- sagging and hyper dry skin;
- age-related degeneration of the subcutaneous layer of tissue in the cheekbones, cheeks, chin and temples;
- loss of tone;
- thin lips.
Advantages
The main advantage of Repler fillers is the use of hyaluronic acid, which is produced by the body at the cellular level independently.
Moreover, the raw materials are of non-animal origin, which ensures 100% compatibility with the human epidermis. However, the advantages of the drugs do not end there. Also worth highlighting:
- long-term effectiveness after injection - the effect lasts for 9-18 months.
- minimally invasive drugs - due to good plasticity and viscous properties, the gel is able to penetrate the necessary layers of the dermis.
- extremely rare side effects, which is associated with the low level of endotoxins contained in the drug.
- reasonable price in relation to high quality.
Hyaluronic acid in Repleri® fillers:
The main component – hyaluronate, contained in the preparations of this line of fillers, is presented in the form of a suspension of weakly stabilized hyaluronic acid, containing gel particles of stabilized hyaluronic acid. The technology for the production of hyaluronic acid, which is part of Repleri, is characterized by minimal changes in its molecules (less than 1%). Due to the non-animal origin of the hyaluronic acid included in the drug, Replery has a high level of biological compatibility, and the risk of developing skin inflammation after administration is minimized. Repleri consists of stabilized hyaluronic acid of natural origin 24 mg/ml and isotonic sodium chloride solution up to 1 ml, thus it is a two-phase drug. Biodegradation A unique property of Replery fillers is the long-lasting effect of the procedure and the pronounced aesthetic appearance of the skin. After the physiological absorption of hyaluronic acid, no traces remain on the skin. Stabilization of hyaluronic acid in Repleri® fillers The aesthetic effect of the procedure is the main indicator after the use of Repleri preparations. Thanks to the stabilized hyaluronic acid included in the composition, the effect of administering the drug is noticeable for a long period of time (up to 1.5 years), depending on the degree of concentration of Repleri. The preparations in the Replery line break down slowly, thanks to the unchanged molecules of hyaluronic acid included in the composition. The elastic particles of the gel in their effect resemble the construction of a frame to fill all the folds, wrinkles and unevenness of the skin, creating an ideal facial contour.
Cost of drugs
You can purchase the invasive drug Repleri for a price ranging from 4-8 thousand rubles per package.
Different types of fillers have different release forms. Thus, drugs numbered 1, 2, 3 and Lip have a syringe volume of 1 ml, No. 4 - 1.5 ml, No. 5 - 2 ml.
However, buying a product on online platforms is quite problematic. This is due to the policy of the manufacturer itself. Its program gives preference only to buyers who can provide a certificate of qualification.
The official website of NovoNexus additionally displays a list of clinics where highly qualified specialists provide services, through whom, accordingly, you can purchase the drug itself.
Advantages of Replery gels:
Cosmetologists note the achievement of maximum results when using products from the Replery line; all patients are very satisfied with the procedure. The effect after the introduction of the filler is noticeable immediately and lasts up to 1.5 years. The fillers in this line are absolutely safe, well tolerated and do not cause side effects. Due to the high plasticity of the insertion material, the procedure is carried out with minimal trauma to the patient. Preparations from the Replery line guarantee the patient safe correction of skin problems, long-term results and minimal trauma. Line of fillers: • Replery 1 – optimal filler for correcting fine lines around the mouth and eyes, eliminating crow's feet and purse-string wrinkles. Designed for introduction into the upper dermal layers of the skin. Available in a sterile glass syringe with a volume of 1 ml. A 30 G injection needle is included separately. • Replery 2 is a drug for eliminating wrinkles and correcting midlines, lip contour, forehead and neck. Indicated for introduction into the middle layers of the dermis. Available in a sterile glass syringe with a volume of 1 ml. A 30 G injection needle is included separately. • Replery 3 is a drug for the correction of medium and deep wrinkles and lips. Indicated for injection into lips and deep wrinkles. Available in a sterile glass syringe with a volume of 1 ml. A 27 G injection needle is included separately. • Replery 4 – designed to eliminate deep wrinkles and create volume, injected into the deep layers of the dermis. Available in a sterile glass syringe with a volume of 1.5 ml. A 26 G injection needle is included separately. • Replery 5 – indicated for cheek and chin enlargement, facial contouring and nose restoration. Available in a sterile glass syringe with a volume of 2 ml. A 23 G injection needle is included separately.
Existing contraindications
To minimize the risk of complications during and after the procedure, it is necessary to identify possible contraindications at an appointment with a cosmetologist, including:
- oncological diseases;
- pregnancy;
- lactation period;
- psychosomatic abnormalities;
- disorders of the cardiovascular system and blood diseases;
- chronic diseases in acute form;
- intolerance to hyaluronic acid;
- predisposition to allergic reactions;
- autoimmune disorders;
- Quincke's edema;
- pathologies of the endocrine system;
- menstruation;
- inflammation and wounds in the area of intended impact;
- tendency to keloid scars;
- rehabilitation period after operations or aggressive cosmetic procedures such as chemical peeling and dermabrasion;
- the presence of subcutaneous implants in the affected area;
- inflammatory and infectious processes;
- herpes;
- anaphylactic shock;
- dermatitis;
- age category up to 18 years;
- general malaise.
Side effects
If all norms and rules are followed, the risk of occurrence is minimized, however, if the cosmetologist is insufficiently qualified or if contraindications are ignored, complications may arise.
Possible side effects if the procedure is not followed:
- swelling, hematomas or inflammation in the areas of invasion;
- allergic reaction to the component composition;
- keloid scars;
- seals at the site of puncture of the skin, which often go away on their own after a couple of weeks;
- necrosis;
- connective tissue fibrosis;
- granulomas;
- contouring filler through the skin;
- migration of the gel to adjacent areas.
If an undesirable result occurs, the cosmetologist injects a product with hyaluronidase properties into the subcutaneous layers. Due to it, the main substance is broken down and the consequences of the procedure are minimized.
Description of the procedure
Using Replery filler will not cause any difficulties for a cosmetologist who knows his business. The procedure involves introducing biogel of the required density into the dermal layers using needles of varying thickness.
Preparation
At the preparatory stage, the specialist collects a complete anamnesis of the client’s health condition and excludes possible contraindications. For some time, the body prepares for further impact on the area that requires correction. At that time:
- It is strictly forbidden to drink coagulants and antibiotics;
- do not drink alcohol, smoke, or eat fatty foods high in salt;
- It is not recommended to visit the gym and subject the body as a whole to physical stress.
Buyanov Sergey Yurievich (Expert Doctor):
People with chronic diseases during exacerbations, especially seasonal ones, should reschedule the procedure until complete clinical remission is achieved.
Administration zones
The use of drugs is possible in the following areas:
- neckline;
- face;
- hand area.
Depending on the area being corrected and the density of the filler itself, the techniques that the cosmetologist can resort to during the session also differ.
Techniques for contouring
- Linear. Often used to inject medium-density dermal fillers into the upper layers of the skin. This technique is characterized by inserting a needle of the required diameter over its entire length at an angle of 30, maximum 40 degrees.
- Fan. Injection occurs according to the principle of the linear method, with the exception of one point - after injecting the gel, the instrument is not removed from the skin layers, but is turned in the opposite direction inside the dermis. After the filler injection continues, the manipulations are repeated several times.
- Mesh. A popular technique for replenishing missing volumes in the area of the cheekbone, temples and cheeks. The gel is introduced in a parallel and perpendicular direction to the permissible depth, which may vary, but not exceed the norm. The result is a “soft” filling effect.
- Sandwich technique. Used to eliminate pronounced wrinkles. At the first stage, the drug is injected into the deep layers at an angle of 30 degrees, and then into the upper layers by changing the inclination of the instrument to 15 degrees.
Chronology of actions
On average, the procedure lasts 40-60 minutes. The maximum can be increased to 2 hours due to the complexity and boundaries of the area being corrected.
Stages:
- Removing decorative cosmetics and eliminating other types of contaminants.
- Cleansing the dermis in the affected area with an antiseptic.
- Applying an anesthetic cream.
- Opening the package of the drug in front of the client, checking the expiration dates and serial number, as well as entering data into the file cabinet.
- Injection of the drug into the affected area using the selected technique.
- Disinfection of skin. If necessary, light massage and application of an anti-inflammatory agent.
How does the procedure take place, in what areas
The introduction of repler fillers does not pose any particular difficulties for an experienced cosmetologist. The instructions for use of the selected product clearly indicate the type of needle required for injection. The denser the filler, the larger the diameter of the needle.
Administration technique
- Before injecting the selected filler, the required area is treated with antiseptics and anesthetics.
- Injections are administered in several doses, dividing the recommended dose into several parts. Thus, the active substance is better and faster absorbed by the body.
- A soothing cream is applied to the treated area.
Necessary actions during the recovery period
You can minimize the risks of developing an inflammatory process by following certain recommendations from cosmetologists:
- in the first few days, avoid sudden changes in temperature, especially excessive heat exposure;
- do not take a hot bath in the first seven days after the end of the rejuvenation process;
- Avoid applying decorative cosmetics and face masks for a while;
- exclude self-massage procedures.
On average, the recovery period after Repler filler injections is fourteen days.
Photos before and after
Healing period
After the procedure you may experience:
- local small bruises in the area of skin puncture;
- hyperemia;
- swelling;
- a feeling of fullness in the area where the dermal filler was inserted;
- pain syndrome.
All these symptoms are acceptable and disappear on their own after a week.
To speed up the rehabilitation period, you need to follow the recommendations of a cosmetologist.
- During the first days, do not use decorative cosmetics, and you should not wash your face with running water or rub the corrected area with your hands or other surfaces.
- You cannot visit the sauna, gym, swimming pool, and you should absolutely not swim in natural bodies of water to avoid infection through microscopic punctures in the skin.
- Refrain from sunbathing and use special protective creams in the summer. Solarium is also taboo - ultraviolet radiation has an adverse effect on the course of the rehabilitation period.
- Do not stay outside for a long time during severe frost.
- Do not engage in physical work or sports.
- Carry out cosmetic procedures that actively affect the skin.
How to administer Repleri
The procedure for administering the drug is quick and almost painless.
- Consultation with a cosmetologist.
- Cleansing the correction area.
- Application of anesthetic cream for a comfortable procedure.
- Administration of the drug.
- Cleansing facial skin.
The whole procedure takes about 30-40 minutes. Over the next 1-3 days, papules and slight swelling will remain on the face - this is the norm.
There should be at least 1 week between each session.
And most importantly, how long does the effect last?
Typically, a course of 3-6 Repleri procedures lasts for at least 8 months. It all depends on the individual characteristics of the body. It is recommended to repeat the course once a year.
If you have any questions regarding individual intolerance or possible contraindications, make an appointment with our cosmetologist. He will give you complete information about Repleri Bior and other biorevitalization drugs.
Attention! All aesthetic plastic surgeries and most cosmetic procedures are strictly contraindicated for pregnant and lactating women. We also do not perform surgical interventions on people whose weight exceeds 110 kg.
Cost of the procedure in clinics
The final cost of the procedure in any clinic will be announced only after consultation with a cosmetologist, during which the local area of influence will be indicated.
In addition to the cost of the drug and the specialist’s work itself, the total amount additionally includes an anesthetic and a disinfectant.
Average price in Moscow: from 10 to 14 thousand rubles.
In cities such as Rostov or Ufa, the cost will be slightly lower: about 8-10 thousand rubles.
Cost of Repler fillers
The price for 1 ml of the drug does not change, but the cost of the drug will vary depending on the labeling. Filler of each marking is produced by the manufacturer in different volumes. There is no need to calculate the cost of the procedure by multiplying the cost of a milliliter by the required quantity, since the optimal amount of the drug is established by the manufacturer. But the doctor may additionally prescribe a filler of a different label.
In general, this is 7,000 rubles. for 1 ml. The first three types of filler are sold in quantities of 1 ml in a syringe, No. 4 - 1.5 ml, No. 5 - 2.5 ml. In addition, you need to take into account that the correction will be symmetrical, and the beauty injection must be done on both the right and left. You will need two syringes, or more, depending on the instructions of the cosmetologist.
The approximate price of 1 ml of the drug is 7,000 rubles
Opinion of cosmetologists
Mostly cosmetologists leave positive reviews about Replery fillers. Specialists are satisfied with the optimal ratio of price and long-lasting results.
However, there are those who do not trust Russian drugs. This is due to the production of the product in China.
The specialist recommends the drug as an excellent biorevitalizant:
The following cosmetologist speaks satisfactorily about the preparations:
From this review it becomes clear the cosmetologist’s negative attitude towards the products:
However, not everyone is confused by Chinese production:
About the drug
The development of the drug was carried out in Russia, and in 2005 it was patented and introduced into salon practice. However, problems with technical support for the production of the drug were resolved by transferring it to China. Therefore, many clients do not know that this is a domestic filler - high-quality and harmless.
filler is an injectable preparation based on stabilized hyaluronic acid of synthetic origin. All similar preparations contain this acid as the main element. It belongs to the natural structural components of the skin, and procedures to replenish its deficiency in places where the skin “sags” restore the youth of the face for a certain period of time.
The main feature of the volumizer is that it provides the client with the opportunity to select a product of the desired label to solve various aesthetic problems associated with skin aging. Few of the imported drugs meet the requirements for facial correction in different age categories. Usually the drug exists in a single version, and is indicated for use for a specific age.
The filler is available in 5 forms, numbered with corresponding numbers. The differences between them lie in the concentration of the stabilizer that holds the acid particles together. Depending on the density, the drugs are designed to correct different problem areas.
The Repleri Lip volumizer has been developed separately for working with the lip area, which is in demand among clients due to its low cost. However, there are reviews about the short-term effect of the filler. In theory, the filler should fix the result for at least 6-12 months, but in practice it is 1-3 months, no more.
