DMAE (Dimethylaminoethanol): what it is, how to take it, benefits and harms, instructions for use

What is DMAE

Dimethylaminoethanol or simply DMAE is a natural substance that is a precursor to acetylcholine.
Belongs to the category of nootropics. It has a similar effect and structure to choline. The only difference is that dimethylaminoethanol is missing one methyl group. This gives DMAE the ability to pass directly through the blood-brain barrier, while choline is first processed in the liver. Because of this, DMAE is a more effective substance, especially in affecting the brain, cognitive functions, concentration, and memory. Like other nootropics, DMAE is beneficial for the brain. The substance increases the saturation of the brain with oxygen, glucose and other useful substances. DMAE also improves mental activity, improves the interaction of individual parts of the brain, which has a positive effect on all its functions. DMAE has no harm to the body, so the supplement is recommended for everyone, regardless of age and other conditions.

DMAE is a powerful antioxidant. It is able to protect cells from damage and the development of negative processes, and also has a rejuvenating effect. DMAE is particularly important in the fight against lipofuscin. This is a toxic garbage pigment, the amount of which increases with age. The accumulation of this substance in cells not only accelerates the aging of the body, but also provokes a huge number of failures and diseases. Scientists have carefully studied dimethylaminoethanol and found that this substance is capable of removing most of the pigment. When the course lasted from several months to 2 years, the concentration of lipofuscin decreased by half, which can be considered a significant mechanism for inhibiting the aging process.

Cream Dmae for face

Reviews of this product indicate that it is very effective . The drug has the same effect as mesotherapy, but it is much less profound. The cream helps increase the elasticity of the skin and normalize water balance. Experts say that Dmae cream can also smooth out facial contours and gradually get rid of fine wrinkles.

This cream can be used by people after twenty years of age to remove pigmentation and inflammation on the skin. In addition, it allows you to normalize the functioning of the sebaceous glands. This vitamin-containing complex does not form an addiction to it and makes the skin healthy and shiny.

Of course, the use of Dmae preparations in mesotherapy is a colossal breakthrough in the cosmetology industry. However, remember that the procedure in question is uncomfortable and painful, and is quite expensive . Moreover, it is impossible to remain young forever - some changes in appearance that appear with age must be learned to be accepted.

Effects of DMAE

Dimethylaminoethanol affects many processes and organs, so it is important to understand how to take DMAE and what effects you can expect from the supplement. Dietary supplements with DMAE are used either for specific indications or for general health promotion and rejuvenation.

Improvement of cognitive functions

One of the most common indications for DMAE is the supplement's effects on cognitive function and brain function. The substance improves memory, ensures mental clarity, and increases efficiency when performing mental tasks. Increasing the level of acetylcholine, as one of the main neurotransmitters, improves:

• Transmission of impulses in the brain;
• Neuromuscular connection;
• Memory;
• Focus and attention;
• Learning ability and speed of thinking.

Some studies show how the substance affects brain function, so drinking DMAE is recommended for anyone who wants to improve the quality of mental work: students during a session, to perform mental tasks, when acquiring large amounts of new knowledge.

Effect on skin and muscles

Many studies show that the use of DMAE has a significant anti-aging effect on the skin. This effect is achieved by increasing the permeability, protective properties of the cell and their fluidity. Taking into account the fact that cell fluidity gradually decreases, the use of the substance can slow down the aging process.

The body especially needs DMAE to reduce sagging skin and muscle atrophy. First of all, this applies to the skin on the neck, jaw, chest, décolleté, and triceps area. Dimethylaminoethanol can often be found in preparations for smoothing wrinkles and other anti-aging cosmetics. You can also combine DMAE with other antioxidants, this will enhance the anti-aging effect

To reduce stress

Modern studies on students during the session have determined a pronounced anti-stress effect of the substance. Therefore, one of the ways to use DMAE is short courses in increased dosages during periods when it is impossible to avoid stress. The substance significantly neutralizes the negative effects of stress, maintains concentration and calm.

To protect the brain

The substance has not only a powerful antioxidant, but also a protective effect for the brain. DMAE acts with phospholipids, which are contained in brain neurons, which reduces oxidative processes and their negative effects.

Another important effect is the fight against free radicals and oxidative processes in cells. DMAE protects cells and suppresses inflammation. This is a proven way to prevent various diseases, from cognitive decline to Alzheimer's disease.

Improved mood and reduced depression

One study found that taking DMAE tablets improved mood. This effect is associated with an increase in dopamine levels, which is facilitated by an increase in acetylcholine. Dopamine is one of the main neurotransmitters responsible for mood and motivation.

DMAE can also be used in combination with other drugs to eliminate depression and other disorders.

ABC of ingredients: DMAE

There are ingredients in the cosmetics market that are the subject of ongoing controversy. Perhaps the most controversial component, which invariably receives the most polarizing opinions, is dimethylaminoethanol, better known as DMAE or DMAE.

Having burst onto the market at the beginning of the 21st century, from the very beginning it caused a lot of heated discussions, the meaning of which mainly boiled down to the fact that drugs with DMAE are promising, but it is too early to recommend them for use, since the mechanism of action is not clear. Conflicting data on the harms and benefits of such drugs have been published.

However, government regulators had their say and decided to approve cosmetics containing DMAE. And finally, these products appeared on the public market. Buyers were promised that thanks to their use, they could significantly improve skin turgor and get rid of hated ptosis. Needless to say, customers welcomed the new product with open arms.

Where does DMAE come from?

DMAE is a naturally occurring substance that is a precursor to the neurotransmitter acetylcholine. Dimethylaminoethanol is able to stimulate the synthesis of phosphatidylcholine, an important element of cell membranes.

The first harbinger of future success was a study in 1973 that showed increased lifespan in mice and fruit flies given DMAE. A little later, DMAE began to be used as a nutritional supplement for athletes. It helped increase physical endurance and improved memory.

By observing athletes taking the supplement, scientists noticed a side effect of skin rejuvenation. This was followed by further experiments on mice and the victorious journey of dimethylaminoethanol into the cosmetics industry began.

The effect is obvious

A significant contribution to the study of the effects of DMAE on the skin was made by Yale Medical University professor Nicholas Perricone and the Johnson & Johnson Research Center.

It must be said that Perricone conducted his first study on only 17 women, however, these results and beautiful pictures are still often used to visually confirm the “lifting in a jar” effect that DMAE was proclaimed to be. Further research by Perricon confirmed the previous results, but something did not work out, and in the end they were not accepted by the scientific world.

However, blinded randomized trials on 200 Johnson & Johnson volunteers in 2002 turned the situation around, surprising many skeptics. When using creams with 3% DMAE for 12 weeks, all volunteers significantly improved skin elasticity, signs of ptosis, bags under the eyes, wrinkles on the forehead and lips and, importantly, no side effects were observed.

Contraindications and harm

The DMAE supplement has beneficial effects and is not harmful. The substance is of natural origin and is found in food products, therefore it is perceived as natural. DMAE has no contraindications, but in some cases the supplement has an individual invigorating or relaxing effect. In such cases, it is undesirable to take the supplement with drugs that can enhance this effect. For example, if DMAE has a sedative effect on a person, it is not advisable to combine the compound with other sedatives. The same applies to the invigorating effect and combination with other energy drinks. This feature of DMAE is not indicated in the instructions for use, as it is of an individual nature.

The only negative effect of the supplement can only appear with a strong increase in dosage. Symptoms include:

• Increased blood pressure;
• Gastrointestinal disorders;
• Headache;
• Nausea;
• Sense of anxiety;
• Insomnia.

What DMAE Can Do

A cosmetologist and esthetician, the official trainer of Genosys, Irina Aleksandrovna Churikova, helped us understand this issue.

DMAE is a popular and effective rejuvenation method, widely used in cosmetology. It is also used for mesotherapy. It is a powerful antioxidant that stabilizes cell membranes, regulates the strength of cell membranes, making them better retain nutrients and less susceptible to aging. DMAE also has a moisturizing effect, strengthens the skin framework and increases muscle tone, resulting in a lifting effect.

Topical application of DMAE addresses the following skin needs:

• ptosis;
• sagging skin;
• deep wrinkles on the face, neck, décolleté;
• double chin;
• decreased muscle tone of the face, neck and décolleté;
• dark spots;
• swelling under the eyes.

The use of DMAE externally does not imply any contraindications. The component is perfectly absorbed by skin of any age.

Find out what antioxidants are and why women age faster without them

How to use

Methods of taking DMAE are indicated in the instructions. It is important to follow the manufacturer's recommendations, since the dosage of the active ingredient per serving may vary between brands. The standard preventive daily dosage ranges from 100 to 250 mg. For a noticeable anti-aging effect, the dosage can be increased to 300-450 mg per day. It is recommended to divide the daily dose into 2-3 parts, taking it with food. For an invigorating effect, you need to take DMAE in the first half of the day.

In sports, higher dosages are used. The daily dose ranges from 500 to 1000 mg. The average course duration is 2-3 months.

To determine that the dosages are selected correctly and DMAE is taken correctly, use the following signs:

• Noticeable improvement in sleep with more realistic and vivid dreams;
• Increased focus and concentration;
• Light twitching sensations in the muscles.

Similar effects occur only when using dosages above 450 mg, therefore they are more relevant for sports than for using the substance for rejuvenating and therapeutic purposes.

Where to find DMAE

Dimethylaminoethanol is found not only in cosmetic products, but also in food. Salmon fish, sardines and anchovies are rich in its content. If your doctor approves, DMAE can also be taken in capsule form.

As for cosmetics, products with DMAE include this component in the name, so it won’t be difficult to find. PERRICONE MD remains one of the most reputable manufacturers - the brand has built its concept around this component from the very beginning.

PERRICONE MD, No Rinse, Instant skin smoothing discs - RUB 3,970, Derma E, Moisturizing cream with DMAE, alpha lipoic acid and vitamin C ester - RUB 1,240.

We also have for you the Cosmetic ABC of a beautiful woman: active ingredients worth knowing

What products contain dimethylaminoethanol?

Of course, demythylaminoethanol can enter the body from regular food. Its highest content is in seafood. These are mainly different types of fatty fish: tuna, trout, salmon, mackerel, etc. They should be your choice. It is recommended to take 250-500 mg of the substance per day, this corresponds to approximately 1-2 capsules, depending on the dosage.

Content in fish per 100 g:

Consumption of approximately 100 grams of fish provides the body with approximately 35% of the daily requirement of demythylaminoethanol. In the case of pink salmon, sockeye salmon and chinook salmon, this figure increases to 47.3%.

Best DMAE on iHerb

You can purchase safe dietary supplements based on DMAE on the popular iHerb website with worldwide delivery. Our editors have selected the most optimal drug options with positive reviews from customers.

DMAE Now Foods capsules

Now Foods DMAE contains 100 vegetable capsules with a dosage of 250 mg. The cost of one such jar is about 8 US dollars. It is recommended to take 1 capsule 1-3 times a day, preferably between meals. Before starting the course, be sure to consult your doctor.

DMAE from Now Foods on iHerb

Source Naturals DMAE Complex

The reliable company Source Naturals produces a DMAE complex in 200 vegetable capsules. In addition to the active substance itself, each capsule also contains: stearic acid, dibasic calcium phosphate, magnesium stearate, modified cellulose gum and colloidal silicon dioxide. It is recommended to take 1-2 tablets per day.

DMAE complex in capsules