Which is better: Dysport, Botox or Xeomin (what are their differences)

BOTOX, DYSPORT or XEOMIN?

What is the difference between Botox, Dysport and Xeomin? Why different prices?

These are the most common questions from patients suffering from facial wrinkles on the forehead, around the eyes and between the eyebrows.
So, in order. First difference

1. Trade name, manufacturer, suppliers.

The drug "Botox" - Allergan company, the Netherlands The drug "Dysport" - the company Ipson, France The drug "Xeomin" - the company Merz, Germany Second difference

2.Number of units entered or Calculation of units.

Due to the dilution characteristics of each drug due to the different volume of expected units in the bottle, the calculation of each of these drugs will be specific.

"Botox" - bottle 100 units "Xeomin" - bottle 50 or 100 units "Dysport" - bottle 300 or 500 units

In this case, the calculation of the input units at one intended point to achieve the desired result will be different. For example, at one point on the forehead to distribute the drug in a muscle with an approximate diameter of 5 cm, you need: 2 units of Botox or 3.5 units of Xeomin or 5 units of Dysport. In order not to measure 3.5 units of Xeomin by markings on the syringe, we reduce the distance between the injection points and increase the number of injected units of Xeomin. Third difference

3. Accordingly, the price will also differ and the time of the effect of “standing” of Botulinum toxin.

"Botox" and "Xeomin" - the consumption is approximately the same, Price = 220 rubles for 1 unit, but the drug "Xeomin" is purified from protein (due to this it is stored at room temperature), and its effect lasts for about 2-4 months, and retains “Live” facial expressions = the doctor will spend more medicine, but the patient will come more often.

“Botox” lasts for 4-6 months, sometimes 8-12 months (for beginners in this business), the calculation of the cost of the procedure for any Botulinum toxin drug is based on the drug “Botox” as a standard.

Well, “Dysport”, 1 unit - 90 rubles, but the number of units administered is approximately 5 times greater than that of other Botulinum toxins, and the diffusion of the drug into the muscles is correspondingly higher and the effect is longer, and “HOLDS STRONGER”

Fourth difference

Only the drug “Xeomin” is officially approved for injection into the middle and lower third of the face, as well as on the neck (for example, correction of the “Rings of Venus” on the neck)

Conclusion:

Do you want a “LIVING FACE” and eliminate the appearance of allergies to protein-COLITE “XEOMIN”!

If you want “AS ALWAYS and like everyone else” - proven results for half a year, proven drug - colitis “Botox”

If you want “It may be expensive, but it will last for a year and so that not a single muscle moves” - inject “Dysport” And most importantly!!!
Strictly follow the doctor's recommendations after the procedure!!! If you abuse alcohol and constantly visit the sauna (especially during the first 2 weeks after the procedure), it neutralizes the effect of any Botulinum toxin! Beauty to you, with respect, Maxim Roslyakov

What kind of drugs are these?

Before you think about which drug is better, you need to fully understand what these drugs are.

Many people mistakenly assume that these are different products. But this is far from true. The fact is that these products are quite similar, since they contain botulinum toxin. This component is considered the main one.

Manufacturers of the listed drugs use various additional components. Despite this, Dysport, Botox or Xeomin have a common goal - smoothing wrinkles on the face and getting rid of hyperhidrosis (excessive sweating).

Botulism toxin causes muscle paralysis, preventing it from contracting. As a result, tension decreases and wrinkles begin to smooth out. After this procedure, a person stops squinting or frowning.

The effect of botulinum toxin does not last forever (about six months), after which you have to go for a repeat procedure.

These products were first used to smooth out wrinkles in 1987. But the popularity of drugs based on botulinum toxin is only growing. For example, the American Society of Plastic Surgeons reported that 7.4 million botulinum toxin A injections were performed in 2021 alone.

Plastic surgeon Elliot Hirsch

Opinion of cosmetologists

Each patient's body is unique. The same drug works differently on different people: for some, the effect appears within 1-2 days, while others expect it within a week. The duration of the result also differs for each patient. Therefore, when choosing “Xeomin” or “Dysport”, the specialist should rely on the results of previous injections or change the drug if it turned out to be ineffective even at the first use.

Research on extending the duration of action of drugs (2020)

Galderma has announced research on Dysport, which is considered the main competitor to Botox.

Experts decided to check whether it was possible to somehow increase the duration of action of botulinum toxin. That is why it was decided to increase the dosage. But the question arose: is it safe for humans?

As is known, before the procedure, the neurotoxin is diluted, taking into account the manufacturer’s instructions. In this study, the single dose was increased.

401 people agreed to participate in the experiment. Their age was 18-65 years. 3/4 of this group were injected with a more concentrated drug, the rest received the usual injections.

What did the study show?

For 9 months, specialists observed the participants. It was found that increasing the dosage does not harm human health.

But the interesting thing is that the best result was in patients who were injected with a drug with a higher concentration.

In addition, the duration of the effect increased to 9 months.

This study showed that if you increase the concentration of Dysport, you can achieve a better and longer-lasting effect without harm to health.

Plastic surgeon John Joseph (Beverly Hills, California)

After that, other products, Xeomin and Botox, underwent the same tests. The result of the experiment is the same.

The reason for this study was the emergence of the newest drug from Revance. It has been studied by the FDA and is expected to receive approval.

As a result, a serious competitor will appear for current neurotoxins, since the effect after Revance lasts up to 7 months.

In order not to lose their position in the market, Dysport manufacturers began to fuss, so they decided to experiment.

But if the dosage increases, the cost of the drug will increase, which will affect the price of the procedure itself. But the good news is that you will not need to visit the doctor as often due to the increase in the duration of the effect.

Indications for use of drugs

Botox, Xeomin and Dysport are recommended for use in the cases listed below.

INDICATIONS

• the presence of pronounced facial wrinkles in the area of ​​the mouth and eyes;
• the appearance of wrinkles on the chin, forehead, neck;
• the need to eliminate facial asymmetry;
• increased sweating, which causes discomfort (hyperhidrosis);
• the need to eliminate sagging soft tissues in the upper eyelid (ptosis).

The component of all three drugs is the same substance - botulinum toxin. That is why their mechanisms of action on soft tissue are so similar.

Botox is a drug manufactured in the USA, the history of which goes back 2 decades. Dysport is produced in France, and Xeomin is produced in Germany. The last two drugs were developed not so long ago, and are considered one of the most modern products in the field of cosmetology, as evidenced by reviews from doctors.

After the administration of such a drug, the muscles lose the ability to contract and become temporarily paralyzed. As a result, wrinkles are smoothed out. This is a safe procedure.

Plastic surgeon Elliot Hirsch

Forehead lift

A new direction in the use of drugs based on botulinum toxin is forehead lifting. Research was conducted in 2021, which confirmed the effectiveness of the method.

Injections are made into the hairline. An experiment has shown that this makes the forehead longer. Of course, the result after plastic surgery is much better, but after a while the effect disappears, a repeat procedure will be required.

29 people participated in the study. Their ages ranged from 29-66 years. They injected Dysport into points on the scalp.

Doctors recorded the results in before and after photos. 2 weeks after the injections, the height of the forehead changed.

The effect was better in patients whose forehead was lower initially. No complications were observed in anyone.

Pore ​​reduction

Perhaps botulinum toxin-based drugs will soon be used to reduce pores.

A study was conducted in which 20 volunteers participated. They were injected with botulinum toxin type A. It was proven that the drug affects the production of sebum. The participants themselves noticed the effect. But research will still continue.

Reviews

OLGA, 37 YEARS OLD:

“I have already had the procedure of administering botulinum toxin more than once.
I tried both Botox and Dysport. I recently assessed the effectiveness of Xeomin. I understood one thing: all these drugs are effective, I don’t see much difference in the results, but the effect can be disappointing in the hands of an incompetent doctor. Once upon a time I was not satisfied with the effectiveness of the procedure, although I tried different means.

But when I changed my cosmetologist, I finally got what I was waiting for, and my face does not have the frozen look that it had before. Therefore, do not look for the difference between drugs, but start looking for a good specialist.”

SOFIA, 35 YEARS OLD:

“Since childhood, I have had the habit of squinting or frowning in the sun.
Of course, this didn’t bother me before, but over time it took its toll. Folds have formed in the area between the eyebrows. I decided to get injections. I was injected with Botox. The result is amazing.

I went for a repeat procedure a year later. My cosmetologist suggested I try Dysport.

At first I was skeptical about the drug, but agreed to the experiment. The interesting thing is that I didn’t notice much of a difference, to be honest. The wrinkles disappeared in this case too.”

How is the recovery period going?

Rehabilitation after Xeomin or Dysport injections is no different.

On average, recovery occurs within 7-14 days.

In the first days after visiting the doctor's office, you may experience skin hyperemia, slight swelling of the tissues, and discomfort at the injection sites - this is considered normal.

To ensure that the result lasts as long as possible, cosmetologists recommend adhering to a number of restrictions throughout the rehabilitation period:

• eliminate alcohol and smoking;
• do not visit saunas, baths, swimming pools and gyms, avoid taking a hot bath;
• refuse solarium, avoid direct sunlight;
• do not take aminoglycoside antibiotics;
• Do not massage the muscles or rub the skin at the injection sites to avoid excessive diffusion of botulinum toxin.

In case of urgent need for antibiotic therapy, you should contact your doctor, he will help you adjust the choice of medication taking into account the botulinum therapy performed.

Don’t forget to use a cream with SPF of at least 30 before going outside - this is a general recommendation, but after the procedure you need to follow it strictly.

Precautionary measures

Side effects

• Allergic reaction.
• Drooping eyebrows due to improper administration of botulinum toxin in the forehead area.
• Raising the outer edge of one or two eyebrows as a result of uneven distribution of botulinum toxin when injected into the brow ridges.
• Ptosis, drooping of the upper eyelid when the medication is injected into the area around the eye.
• Asymmetry of the smile, impaired articulation and chewing with injections in the lower third of the face.
• Feeling of tingling, numbness, burning or pain at the injection site, paresthesia.
• Mild headache, dizziness, nausea.
• Long-lasting hyperemia and swelling in the injection area.
• Microhematomas and ecchymoses.
• Mild to moderate muscle pain.
• Temperature increase.

Buyanov Sergey Yurievich (Expert Doctor):

A headache can go from a mild form to a migraine-like one. A similar side effect is observed with injections into the frontal area, especially with deep penetration of the needle. That is why it is not recommended to ignore this effect and report it to your doctor.

Contraindications

• Intolerance to botulinum toxin or any component included in the injection solution.
• Pregnancy and lactation.
• Treatment with antibacterial drugs from the aminoglycoside group (Amikacin, Kanamycin, Neomycin, Gentamicin, Streptomycin).
• Disturbance of neuromuscular transmission.
• Age up to 18 years.
• It is not recommended to conduct botulinum therapy sessions in the first days of the menstrual cycle.
• Fever of any origin, as well as acute infectious diseases.
• Exacerbation of herpetic infection.
• Exacerbation of any chronic somatic disease.
• Blood clotting disorder.

Comparative list of botulinum toxin composition:

Activity units represent the dose of drugs. One unit of activity is equal to the median lethal dosage (LD50) for medium-sized female mice. It has been roughly established that 1 unit (U) of Botox is equivalent in activity to 1 unit of Xeomin, Neuronox, Lantox and Relatox, as well as 3 units of Dysport. However, it is not worth equating them in this situation. As practice shows, with equivalent administration of various medications, different durations of action and severity of effects are observed. This is explained by the fact that each series of a substance can differ in activity by +/- 10%.

Particle size (molecular weight) - the smaller the size of the elements, the higher the diffusion of the drug, and the larger the area that can be affected by one injection. In the hands of an inexperienced physician, a high degree of diffusion can lead to side effects due to the penetration of the substance into neighboring muscles. However, this feature will provide a more uniform effect on the muscle and a quick effect.

Albumin is the main stabilizing component. This protein has the following functions: combining botulinum toxin, limiting the diffusion of the substance, including inhibiting its activity. The more albumin, the subtler and softer its effect.

Additional elements , as well as their impact on the stability, diffusion and dynamics of drugs, are very difficult to evaluate and accurately compare drugs with each other.