Contractubex for wrinkles on the face: reviews from cosmetologists and the use of the drug under the eyes and a review of possible contraindications

What kind of remedy is this?

The components of the gel are selected in such a way that they not only potentiate each other’s action, but also lead to an increase in the production of hyaluronic acid.

When it is deficient, the skin actively ages, becomes loose and dry; even young people can experience this.

Contractubex is a real stimulator of skin regeneration . It effectively polishes and smoothes out any scars, eliminates wrinkles, stretch marks, acne marks, brightens the skin and evens out its tone, revitalizes and enhances oxygen absorption.

Active substances

Contratubex really helps get rid of wrinkles, the secret is in the special selection of ingredients.

The main active components are:

Heparin is an anticoagulant known in medicine, and in cosmetology it is a product that improves blood circulation in the epidermis, retains water in cells, and relieves minor inflammation, bruising and swelling. It normalizes metabolism in the shallow layers of the dermis and has an antiproliferative effect on the skin. This complex effect of heparin alone already helps smooth out deep scars and folds on the skin. When applied, the skin becomes more hydrated and elastic.
Allantoin is a highly effective cosmetic product based on sprouted wheat grains and comfrey roots. It powerfully accelerates wound healing, eliminates itching and redness, enhances skin regeneration, enhances the ability of tissues to retain water in the dermis, increases their permeability to other active substances of the gel, improves blood circulation, and saturates cells with oxygen. Allantoin, being a keratolytic, cleanses the skin by exfoliating dead cells. As a result, a rejuvenating effect and smoothing of wrinkles are achieved.
Cepalin (extractive extract from Serae onion) - is responsible for bactericidal and anti-inflammatory effects, relieves swelling, improves collagen synthesis. Its deficiency is the cause of wrinkles. Cepalin prevents the ducts of the sebaceous glands from becoming clogged, as a result of which the skin acquires an even tone and smoothness.

Considering the effect of the main ingredients, even to an ordinary person ignorant of medicine, it becomes obvious that this remedy can be successfully used in the fight against wrinkles on the face.

Expert opinion

Shustova Olga Leonidovna

Obstetrician-gynecologist of the highest category

“Until recently, I paid little attention to the feedback from my patients about the miracle drug Contractubex. But we had to treat one patient with a deep scar on her face after a car accident. So I was convinced of the changes in her facial skin. It turned out that she applied the gel not only to the scar, but also to her face and eyelids. Now I prescribe the gel to my other patients with ease and full responsibility. There have never been any negative reviews. The question may arise: why don’t cosmetologists openly prescribe the drug? The problem comes down to medical ethics; there are no such prescriptions in the official instructions, although practice shows the opposite.”

What is it like?

Contractubex is produced in the form of a thick gel in metal tubes of 20 and 50 g. The composition contains main and auxiliary substances, the action of which is aimed at combating scars and scars. It also works well on stretch marks.

Contractubex contains substances that stimulate the production of hyaluronic acid, which is extremely important for maintaining youthful skin. Initially, the gel is intended for healing scars and removing scars. At the same time, many use the product as an anti-aging cream. This is not surprising, because its composition causes skin smoothing.

Contractubex against wrinkles began to be actively used by young girls and older ladies. Among the good reviews there is also criticism, but this makes no less willing to experience the rejuvenating effect of the new German development.

Chemical composition

All substances in the composition are carefully selected and tested in laboratory conditions.

What does Contractubex consist of:

Heparin - smoothes wrinkles and scars, helps to cope with bags under the eyes and strengthens blood vessels, moisturizes the skin, while increasing elasticity;
Allantoin – is responsible for the regenerative effect, normalizes blood circulation in compacted areas, softens old scars;
Extract from Serae onion - has an anti-inflammatory and bactericidal effect, helps improve collagen synthesis, which gives a resorption effect.

Indications

Contractubex is used for the following indications (according to the instructions):

Keloid and hypertrophic scars after operations, burns, injuries;
Prevention of scarring after injury or surgery;
Joint contracture;
Tendon contractures;
Stretch marks after childbirth.

Benefits for the skin

Contractubex for facial wrinkles is used because it stimulates regeneration at the cellular level. In addition, the gel has anti-inflammatory, antithrombic and keratolytic effects. The product can smooth out even old scars, which already indicates its effectiveness in eliminating wrinkles.

The drug is useful for the skin not only in terms of smoothing, but also for improving nutrition, hydration and preventing congestion. It was experimentally established that the gel penetrates into the deep layers of the skin within 4 hours, but does not spread throughout the body.

Ointment storage

The drug Contractubex should be stored in its original cardboard packaging. The optimal temperature is up to 25°C. You need to choose a place protected from the sun. Access for children must be strictly limited.

Advantages and disadvantages

The advantages of the drug are not diminished in any way even with its direct use and intended purpose . The tasks assigned to it are to remove scars and scars, stretch marks, pimples, etc. Contractubex fulfills 100%.

Disadvantages include low effectiveness for old scars.

Due to its composition, the gel has recently become widely used by cosmetologists . It removes wrinkles no worse than branded anti-aging creams. Another advantage of the drug is its natural composition.

The disadvantages of the product include the small volume of the tube and a rather high price.

Composition and release form

The drug is available in gel form . The size of metal tubes is 20 or 50 g, packed in cardboard boxes. Some people look for Contractubex ointment and cream in pharmacies, but the drug does not have such release forms.

The product is a thick brown gel with a noticeable onion smell.

The active ingredients are onion extract, allantoin and heparin.

Also contains excipients:

Xanthan gum is a natural gelling agent that preserves the structure of the skin well.
Sorbic acid is a preservative.
Purified water – creates the necessary consistency.
Macrogol (polyethylene glycol) – acts as a gelling agent and solvent.
Methyl parahydroxybenzoate is a synthetic stabilizer and preservative.
Flavored oil – adds a pleasant aroma to the preparation.

Contractubex is also available in the form of a patch. Its difference is that it does not contain heparin. Of course, it does not apply to wrinkles.

Contratubex is more affordable than many anti-aging creams.

The discussion of the results

The results obtained give reason to believe that the treatment of pathological skin scars using electrophoresis with Fermenkol has therapeutic effectiveness . Electrophoresis of the collagenase preparation promotes a statistically significant regression of such parameters as the type of scar (by reducing the severity of hypertrophy); consistency of the scar (its density decreases); color of the scar (hyperemia decreases, the erythematous color of the scar becomes less intense). It also tends to reduce the severity of subjective sensations : tension, soreness, itching. Analysis of photographs of patients before and after a course of therapy shows a visual slight decrease in the severity of scar erythema, as well as a tendency to change its configuration due to the involution of its least hypertrophic areas. At the same time, the effectiveness of scar treatment with electrophoresis with Fermenkol depends on the age of the scar: thus, the consistency of a “young” fragile scar becomes significantly less dense, while stronger old scars practically do not change in consistency. However, even scars more than 12 months old are also susceptible, although to a lesser extent, to the action of the drug: thus, patients note a decrease in the tension of the scar, and in the presence of contractures, an increase in mobility, the degree of extension in the joint covered by the contracture.

The clinical sign of a scar, the most sensitive to the effects of therapy, turned out to be subjective sensations. Thus, the vast majority of patients primarily indicate a decrease in tension, pain and itching of the scar (by 50%; Fig. 1). The next most important sign is the severity of erythema (by 36%; Fig. 1). A change in this feature can be seen when studying photographic materials. Also, when palpating scars, you can notice a decrease in their density under the influence of therapy (by 25%; Fig. 1). Finally, the change in scar type (by 22%; Fig. 1) is significant mainly for young scars (Fig. 4), and always occurs more slowly than changes in other parameters.

According to the results of a study of the comparative effectiveness of therapy for pathological scars in the main and control groups of patients, it turned out that the maximum effectiveness of therapy for pathological skin scars occurred when using electrophoresis with Fermenkol . Only this drug reliably changed all the clinical parameters we studied.

The next most effective treatment was a course of phonophoresis therapy with the drug Contractubex. The consistency of scars decreased slightly (by 24%, Fig. 2), erythema decreased (by 31%, Fig. 2), subjective sensations were comparable to those during fermenkol therapy. These changes turned out to be statistically unreliable. Manufacturers recommend using this drug in long courses, coinciding with the timing of the physiological involution of the scar, by simply rubbing it into the scar. The use of phonophoresis to administer the drug could ensure its deeper penetration and, accordingly, greater effectiveness in shorter periods of time. Also, the very effect of ultrasound on scar tissue cannot be ruled out; in modern physiotherapy, ultrasound therapy is widely used to treat scars.

The use of electrophoresis with lidase affected only the subjective sensations of patients, practically without changing other parameters (Fig. 3). Thus, the widely used therapy of pathological scars with hyaluronidase preparations was ineffective in the present study.

The main task of treating pathological skin scars is mainly to change the type of scar, to transform a hypertrophic, keloid scar into a normotrophic one. However, the results of the work show that this particular parameter turns out to be the most rigid and less susceptible to regression. Thus, the regression of scars after the use of one course of Fermenkol electrophoresis, which includes 10-15 procedures, does not have sufficient visual severity, as indicated by the analysis of photographs of patients. This necessitates the use of not one, but several, even many repeated courses of enzyme therapy for scars, in combination with other pathogenetically based methods of therapy. Also, from our point of view, an indirect indicator of the effectiveness of Fermenkol can be the fact that patients preferred Fermenkol therapy , as evidenced by the maximum number of patients in the first group.

Indications for use

Instructions for use indicate that the drug promotes the resorption of scars and the healing of damaged skin areas resulting from a variety of reasons..

In addition, the product can replace anti-aging creams, as it perfectly smooths out wrinkles, relieves swelling and inflammation after unsuccessful laser surgeries, tattoo removal, and peeling.

Indications for use in cosmetology:

increased skin dryness;
early appearance of wrinkles;
deep expression wrinkles;
scars after squeezing out acne;
allergic reactions with severe skin irritation;
sunburn;
age spots, incl. and age.

Basic application rules

Before using the drug, it is advisable to consult a doctor who will select the appropriate regimen and dose, because every skin is individual.

NOTE!

To detect an allergic reaction, upon first use, apply a small amount of gel to the surface of the wrist (the most delicate skin) and rub gently.

If after 45 minutes no redness or itching appears, you can safely use the drug in the future.

With regular use, it is necessary to protect the skin from exposure to direct sunlight, cold and intense massage..

Therefore, it is best to apply the product at night for 2 months to obtain a clear effect. Then you should take a break for the same amount of time, after which the course can be repeated.

Contingent of examined patients and research methods

The study included a screening phase, which began 1 to 2 days before the first dose of the study drug. The purpose of screening is to determine whether the patient meets inclusion/exclusion criteria. After being assigned to treatment groups, patients were given a constant dosage regimen.

All patients with excess (hypertrophic and keloid) skin scars under observation were divided into three groups. The main group that received Fermenkol included 21 patients. Comparison group 1 included 8 patients; they were treated with the drug Lidaza. Comparison group 2 - 9 patients - received the drug Contractubex. Treatment methods were offered to patients to choose from.

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Patients in all groups did not have concomitant severe chronic diseases and did not receive additional drug therapy. In the main group, the duration of the scars was up to 12 months in 15 people (on average 7.7 months), in 6 people - more than 12 months (on average 81 months).

During the work, two patients of the main group dropped out of the study: one due to refusal to participate, the other was excluded due to a reaction that developed after the first procedure of electrophoresis with Fermenkol, which was expressed in the development of hyperemia of the skin in the electrophoresis zone, the appearance of intense itching, pain, and a rise in body temperature to 37.8 degrees. These phenomena of acute dermatitis were stopped by local use of lotions and glucocorticoid drugs; Antihistamines are prescribed orally. No drug intolerance was observed in the remaining patients of all groups.

Methods of using drugs

Fermencol was administered by electrophoresis. The base of the Fermenkol solution for electrophoresis was prepared according to the manufacturer's instructions (0.2% solution of potassium chloride in distilled water with the addition of 2 mM calcium chloride and hydrochloric acid in an amount equal to the pH of the solution at 5.0). The specified composition of the recipe is due to the following circumstances. Fermenkol is a multienzyme complex. Due to the fact that these enzymes have proteolytic activity, they are active against each other, as a result of which the concentration of enzymes in the solution decreases over time. The introduction of 2 mM calcium chloride as a stabilizer allows the enzyme activity to be maintained in solution for a sufficiently long time, which is especially important in cases where the entire volume is not consumed immediately, but gradually.

Giving the solution a pH of 5.0-5.5 increases the efficiency of administering the drug by electrophoresis. We used a solution of the drug with a concentration of 0.1 mg/ml, as the most economical and recommended by the manufacturer as optimal for typical applications. The required volume of solution was calculated as follows: per 1 cm² of scar, approximately 0.5 ml of Fermenkol solution is required. The pad was moistened with Fermenkol solution, the enzyme was injected from the anode, the current density was no more than 0.1 mA/cm² when the scar was localized on the torso or limbs and no more than 0.05 mA/cm² when the scar was localized on the face. The duration of the procedure is about 20 minutes (no more than 30). The duration of the course for correction of hypertrophic scars is 10–15 procedures.

Find out which method of correcting scars and stretch marks is optimal for you!

doctor Svetlana Viktorovna Ogorodnikova.

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Lidase was also introduced by electrophoresis according to the procedure given below. The drug in an amount of 64 U was dissolved in 30 ml of acetate buffer. The gasket was wetted with Lidase solution, the enzyme was introduced from the anode, the current density was no more than 0.1 mA/cm². The duration of the procedure is about 20 minutes (no more than 30). The duration of the course for correction of hypertrophic scars is 10–15 procedures.

Contractubex was administered using phonophoresis daily, the drug was applied to the scar area. Administration mode: power no more than 0.2 W/cm² when the scar is localized on the face and no more than 0.4 W/cm² when localized on the torso and limbs. The duration of the procedure is no more than 5 minutes for each area, but no more than 10 minutes of total duration. Course duration is 10-15 procedures. All drugs were supplied by an independent organization, Natur Product LLC (St. Petersburg).

Research methods

In the course of comparative studies, the dynamics of changes in the state of scar tissue were determined during the use of drugs for the treatment and correction of skin scars. Before the start of the study, the nature of the scars was assessed according to four signs and photographed before use. One assessment of the nature of scars based on four signs was repeated after 3–4 procedures and after 7–8 procedures. At the end of the use of Fermenkol and comparison drugs, the nature of the scars was again assessed according to four signs and photographed. The number of procedures, all data obtained was recorded in individual patient records. The photographs were saved electronically.

Basic clinical parameters of skin scars

P1: scar type

normotrophic - code 0;
hypertrophic homogeneous - code 1;
hypertrophic with nodules - code 2;
noticeable keloid - code 3;
pronounced keloid - code 4.

P2: rumen consistency

normal - code 0;
small seal - code 1;
pronounced induration - code 2.

PZ: scar color

healthy skin - code 0;
slight erythema - code 1;
severe erythema - code 2.

P 4: scar sensitivity

voltage - code 0;
itching - code 1;
burning - code 2;
pain - code 3.

Statistical processing

The experimental data obtained during the study were processed using the STATISTICA 6.0 package for a personal computer using nonparametric methods using the Wilcoxon test. A probability of p < 0.05 was considered sufficient to conclude that the differences in the data obtained in the study were statistically significant.

Instructions for use

Basic application rules:

The gel is used daily, 2 times a day, for at least 2 months. Application at night is mandatory.
Apply a thin layer directly to wrinkles, using gentle massaging movements - from the center of the face to the periphery. There is no need to massage for a long time, since the gel is quickly absorbed without leaving any traces.
The skin should be pre-cleaned (from makeup) and lightly steamed for 5-7 minutes over chamomile decoction. This way the gel will be absorbed deeper and better. Its single dose is only 0.5 cm.
Particular care is required when applying around the eyes. Here the movements should be in the form of gentle slapping of the fingertips into the area of the webs.
Avoid contact of the gel with mucous membranes.

You should not expect results in a week; the first effect is usually visible only after a month.

Possible contraindications

Contractubex gel has virtually no contraindications . It is suitable for the prevention and elimination of signs of skin aging in women, regardless of age. It is better to ask your cosmetologist about the possibility of combining Contractubex with other care products.

During pregnancy and breastfeeding, the use of Contractubex is not prohibited. It can be used even in infants from 6 months old - this has been clinically proven.

The gel should not be used on skin lesions that have not healed and should not be allowed to come into contact with the mucous membrane..

Contractubex for wrinkles: customer reviews

Andrey: Due to non-compliance with safety precautions, toxic chemicals got into my hand at work, so I received a chemical burn. When the wounds healed, I began to smear the wound with Contractubex gel. Over time, the scars smoothed out and completely faded. Therefore, I am very pleased with the drug.

Igor: When I was young, I received a knife wound to the face, which left an ugly scar. After I started using the ointment, the scar did not completely disappear, but became less noticeable visually. I am very pleased with the result.

Irina: I bought the gel to get rid of a stitch after a caesarean section. At the same time, I understood that it was unlikely that I would be able to completely get rid of the scar. After I used 2 tubes, the seam changed color, its convexity disappeared, and visually almost merged with the surrounding skin. I don’t regret the money spent and I’m satisfied with the result.

The editors recommend:

average price

You can buy Contractubex without a prescription at a pharmacy chain in any city. This gel is available for sale in tubes of 20 g and 50 g. There are also tubes of 10 g of domestic production, but using the same technology.

The average price for the drug is 550-1000 rubles by volume.

The shelf life of the drug is 4 years. It should be stored out of the reach of children, away from sunlight at room temperature. After the expiration date, it is prohibited to use the product.

From everything described above, you can make an input - you can and should use Contractubex for wrinkles . Numerous reviews speak of truly impressive results.

When combining it with other remedies, it is better to consult a dermatologist.

Application in cosmetology

In cosmetology, Contractubex for wrinkles has been used not so long ago. Experts recommend that you carefully study the instructions first in order to understand what effect you can expect.

How to use the gel:

The skin is well cleaned with a scrub and washed under water.
The face is steamed (you can use herbal decoctions).
The gel is applied to problem areas by lightly rubbing.

To combat wrinkles, it is recommended to use the gel every day for 6-8 weeks. After a short break, you can repeat the course again.

Can the gel get rid of wrinkles in 2 months?

Yes No of course

It must be remembered that the gel is intended to combat scars and scars, so it is likely that there will be no effect in eliminating wrinkles. Individual factors that provoke skin aging should be taken into account.

Use of the drug "Kontraktubeks" for wrinkles: active substances and principle of action + reviews from women